Angus “Mac” MacGyver, with help from Jack Dalton and Nikki Carpenter, infiltrate a party to steal a biological weapon. However, as Mac and Jack meet up with Nikki, they find her held hostage by John Kendrick. Mac gives up the bioweapon, but Kendrick shoots both him and Nikki. In the present, Nikki is dead, and Mac is on holiday, when his boss, Patricia Thornton of DXS, arrives. Thornton shows a lab where the bioweapon was used, and calls Mac and Jack back in to help. With information stuck on Nikki’s hard drive, the two recruit hacker and convict Riley Davis, who tracks Kendrick to San Francisco. The group not only finds Kendrick, but also discovers that Nikki is alive and working with him for another group. After capturing them both, Mac finds out that Nikki has already sold the bioweapon to someone, who plans on making it airborne via a bomb. Mac finds the bio-weapon and extracts it from the bomb before it explodes. A few days later, Mac is at home burning photos of Nikki, when Jack, Riley, and Thornton come to meet him. Thornton tells the group that Nikki’s betrayal has caused knowledge of the DXS to become compromised, so they have shutdown and relocate, under a new name. Mac chooses the name Phoenix. Elsewhere, Nikki is in handcuffs, being transported by federal authorities in a car. As the car exits a tunnel, the driver and passenger hear a car door slam, where they see that Nikki has disappeared, leaving the cuffs and a hair-pin behind.
Original air date: September 23, 2016
Writter: Peter M. Lenkov, Paul Downs Colaizzo, Peter M. Lenkov